Yong-Hwee Eddie Loh: Ph.D. student

Current Research

My research focuses on the genomic evolution of East African cichlids. Cichlid fishes from the East African Rift lakes Victoria, Tanganyika and Malawi represent a preeminent example of replicated and rapid evolutionary radiation. Tremendous phenotypic and behavioral diversity among species and lineages have evolved within a short period of time, while retaining a backdrop of genomic similarity. It is thus within this background expectation of similarity that I study the genetic elements displaying high levels of variation between species, in order to uncover their functionalities that makes organisms distinct, as well as the molecular mechanisms that generates and maintains such genetic diversity. In other words, my studies are initiated based on genetic variations in closely related and genetically similar species, as opposed to the diametrically opposite strategy of investigating functionalities via sequence conservation across diverse species.
I possess a M.S. in Bioinformatics from the National University of Singapore and prior to joining Georgia Tech, I was involved in research on the fugu (Fugu rubripes) and elephant shark (Callorhinchus milii) systems.

Publications from Singapore:

Loh YHE, Brenner S, Venkatesh B. 2008. Investigation of loss and gain of introns in the compact genomes of pufferfishes (fugu and Tetraodon). Mol. Biol. Evol. 25(3):526-535. (PDF)

Venkatesh B, Kirkness EF, Loh YHE, Halpern AL, Lee AP, Johnson J, Dandona N, Viswanathan LD, Tay A, Venter JC, Strausberg RL, Brenner S. 2007. Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii) genome. PLoS Biol. 5(4):e101. (PDF)

Venkatesh B, Kirkness EF, Loh YHE, Halpern AL, Lee AP, Johnson J, Dandona N, Viswanathan LD, Tay A, Venter JC, Strausberg RL, Brenner S. 2006. Ancient noncoding elements conserved in the human genome. Science 314:1892. (PDF)

Loh YHE, Christoffels A, Brenner S, Hunziker W, Venkatesh B. 2004. Extensive expansion of the claudin gene family in the teleost fish, Fugu rubripes. Genome Res. 14(7):1248-57. (PDF)